BDBM362460 Roche-Dataset for PDE10A, Compound 215::US10562916, Compound 20::US9834564, Compound 20

SMILES Cn1cc(nc1CCc1cnc2ccccc2n1)-c1ccccc1

InChI Key InChIKey=POYATVYDWRIRCE-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 362460   

TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Sunovion Pharmaceuticals

US Patent
LigandPNGBDBM362460(Roche-Dataset for PDE10A, Compound 215 | US1056291...)
Affinity DataIC50: <500nMAssay Description:The activities of the compounds were determined using the Molecular Devices IMAP PDE Fluorescence Polarization assay using recombinant human PDE-10 e...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Sunovion Pharmaceuticals

US Patent
LigandPNGBDBM362460(Roche-Dataset for PDE10A, Compound 215 | US1056291...)
Affinity DataIC50:  21nMAssay Description:Human PDE10A IC50 values were determined by using purified enzyme (Biomol cat. # SE-534) in a scintillation proximity assay (SPA) in 96 well plates (...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Sunovion Pharmaceuticals

US Patent
LigandPNGBDBM362460(Roche-Dataset for PDE10A, Compound 215 | US1056291...)
Affinity DataIC50: <500nMAssay Description:In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent