BDBM362460 Roche-Dataset for PDE10A, Compound 215::US10562916, Compound 20::US9834564, Compound 20
SMILES Cn1cc(nc1CCc1cnc2ccccc2n1)-c1ccccc1
InChI Key InChIKey=POYATVYDWRIRCE-UHFFFAOYSA-N
Data 3 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 3 hits for monomerid = 362460
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Sunovion Pharmaceuticals
US Patent
Sunovion Pharmaceuticals
US Patent
Affinity DataIC50: <500nMAssay Description:The activities of the compounds were determined using the Molecular Devices IMAP PDE Fluorescence Polarization assay using recombinant human PDE-10 e...More data for this Ligand-Target Pair
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Sunovion Pharmaceuticals
US Patent
Sunovion Pharmaceuticals
US Patent
Affinity DataIC50: 21nMAssay Description:Human PDE10A IC50 values were determined by using purified enzyme (Biomol cat. # SE-534) in a scintillation proximity assay (SPA) in 96 well plates (...More data for this Ligand-Target Pair
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Sunovion Pharmaceuticals
US Patent
Sunovion Pharmaceuticals
US Patent
Affinity DataIC50: <500nMAssay Description:In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...More data for this Ligand-Target Pair