BDBM362828 US9840503, Example 1::trans-4-[3-(Butylamino)-8-(morpholin-4-ylmethyl)pyrimido[4,5-c]isoquinolin-5(6H)-yl]cyclohexanol

SMILES CCCCNc1ncc2-c3ccc(CN4CCOCC4)cc3CN([C@H]3CC[C@H](O)CC3)c2n1

InChI Key InChIKey=MWSLVORBGRTVRI-HZCBDIJESA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 362828   

TargetTyrosine-protein kinase receptor UFO(Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM362828(US9840503, Example 1 | trans-4-[3-(Butylamino)-8-(...)
Affinity DataIC50: >1.00E+3nMAssay Description:The assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.5 ul test compounds dissolved in DMSO were transfe...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase receptor TYRO3(Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM362828(US9840503, Example 1 | trans-4-[3-(Butylamino)-8-(...)
Affinity DataIC50:  550nMAssay Description:The assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.5 ul test compounds dissolved in DMSO were transfe...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase Mer(Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM362828(US9840503, Example 1 | trans-4-[3-(Butylamino)-8-(...)
Affinity DataIC50:  550nMAssay Description:The assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.5 ul test compounds dissolved in DMSO were transfe...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent