BDBM362844 (R)-(8-methyl-3-(5- methylfuran-2-yl)-5,6-dihydro- [1,2,4]triazolo[4,3-a]pyrazin- 7(8H)-yl)(2,3,4- trifluorophenyl)methanone::US9840508, Compound 6

SMILES C[C@H]1N(CCn2c1nnc2-c1ccc(C)o1)C(=O)c1ccc(F)c(F)c1F

InChI Key InChIKey=JGNKOQCRHUJLFY-SNVBAGLBSA-N

Data  4 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 362844   

TargetNeuromedin-K receptor(Homo sapiens (Human))
Oged

US Patent
LigandPNGBDBM362844((R)-(8-methyl-3-(5- methylfuran-2-yl)-5,6-dihydro-...)
Affinity DataKi:  74nMAssay Description:The ability of compounds of the invention to inhibit the binding of the NK-3 receptor selective antagonist 3H-SB222200 was assessed by an in vitro ra...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNeuromedin-K receptor(Homo sapiens (Human))
Oged

US Patent
LigandPNGBDBM362844((R)-(8-methyl-3-(5- methylfuran-2-yl)-5,6-dihydro-...)
Affinity DataKi:  74nMAssay Description:The ability of compounds of the invention to inhibit the binding of the NK-3 receptor selective antagonist 3H-SB222200 was assessed by an in vitro ra...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSubstance-K receptor(Homo sapiens (Human))
Oged

US Patent
LigandPNGBDBM362844((R)-(8-methyl-3-(5- methylfuran-2-yl)-5,6-dihydro-...)
Affinity DataKi: >3.00E+4nMAssay Description:The affinity of compounds of the invention for the NK-2 receptor was evaluated in CHO recombinant cells which express the human NK-2 receptor. Membra...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSubstance-P receptor(Homo sapiens (Human))
Oged

US Patent
LigandPNGBDBM362844((R)-(8-methyl-3-(5- methylfuran-2-yl)-5,6-dihydro-...)
Affinity DataKi: >3.00E+4nMAssay Description:The affinity of compounds of the invention for the NK-1 receptor was evaluated in CHO recombinant cells which express the human NK-1 receptor. Membra...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNeuromedin-K receptor(Homo sapiens (Human))
Oged

US Patent
LigandPNGBDBM362844((R)-(8-methyl-3-(5- methylfuran-2-yl)-5,6-dihydro-...)
Affinity DataIC50:  99nMAssay Description:The ability of compounds of the invention to inhibit the binding of the NK-3 receptor selective antagonist 3H-SB222200 was assessed by an in vitro ra...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent