BDBM363483 4-(9-(2-hydroxy-2-(2-methyl-6- (1H-tetrazol-1-yl)pyridin-3- yl)ethyl)-1-oxa-4,9- diazaspiro[5.5]undecan-4-yl)-3- methylfuran-2(5H)-one (single diastereomer, absolute stereochemistry not established)::US9850245, Example 22A::US9850245, Example 22B

SMILES CC1=C(COC1=O)N1CCOC2(CCN(CC(O)c3ccc(nc3C)-n3cnnn3)CC2)C1

InChI Key InChIKey=WVRMJKIGUCYMPF-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 363483   

TargetATP-sensitive inward rectifier potassium channel 1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM363483(4-(9-(2-hydroxy-2-(2-methyl-6- (1H-tetrazol-1-yl)p...)
Affinity DataIC50:  29nMAssay Description:Blocking of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetATP-sensitive inward rectifier potassium channel 1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM363483(4-(9-(2-hydroxy-2-(2-methyl-6- (1H-tetrazol-1-yl)p...)
Affinity DataIC50:  11nMAssay Description:Blocking of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent