BDBM364474 N-[6-(1-hydroxy-1-methylethyl)-2- phenyl-2H-pyrazolo[4,3-b]pyridin- 3-yl]-3-(1-methyl-1H-pyrazol-3-yl)- 4-(trifluoromethyl)benzamide::US9862707, Example 48::US9862707, Example 49

SMILES Cn1ccc(n1)-c1cc(ccc1C(F)(F)F)C(=O)Nc1n(nc2cc(cnc12)C(C)(C)O)-c1ccccc1

InChI Key InChIKey=ZFLNPQMSUGXZTP-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 364474   

TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM364474(N-[6-(1-hydroxy-1-methylethyl)-2- phenyl-2H-pyrazo...)
Affinity DataIC50:  4.60nMAssay Description:TrkA functional activity was measured using a DiscoverX PathHunter assay. In this assay, U2OS cells express the human TrkA receptor as a fusion with ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM364474(N-[6-(1-hydroxy-1-methylethyl)-2- phenyl-2H-pyrazo...)
Affinity DataIC50:  5.20nMAssay Description:TrkA functional activity was measured using a DiscoverX PathHunter assay. In this assay, U2OS cells express the human TrkA receptor as a fusion with ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent