BDBM364490 (R or S)-2-chloro-N-[6-(1,2- dihydroxyethyl)-2-phenyl-2H- pyrazolo[4,3-b]pyridin-3-yl]-5- pyrimidin-2-yl-4- (trifluoromethyl)benzamide, isomer A::US9862707, Example 64::US9862707, Example 65

SMILES OCC(O)c1cnc2c(NC(=O)c3cc(-c4ncccn4)c(cc3Cl)C(F)(F)F)n(nc2c1)-c1ccccc1

InChI Key InChIKey=LUHUSFQQMLZGRN-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 364490   

TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM364490((R or S)-2-chloro-N-[6-(1,2- dihydroxyethyl)-2-phe...)
Affinity DataIC50:  29nMAssay Description:TrkA functional activity was measured using a DiscoverX PathHunter assay. In this assay, U2OS cells express the human TrkA receptor as a fusion with ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM364490((R or S)-2-chloro-N-[6-(1,2- dihydroxyethyl)-2-phe...)
Affinity DataIC50:  15nMAssay Description:TrkA functional activity was measured using a DiscoverX PathHunter assay. In this assay, U2OS cells express the human TrkA receptor as a fusion with ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent