BDBM365131 6-methyl-4-(2-((1-methyl- 1H-pyrazol-5- yl)amino)pyrimidin-4-yl)- 9-propyl-8,9-dihydro- 1,2,2a1,6- tetraazabenzo[cd]azulen- 7(6H)-one::US10517878, Compound I-64::US10842799, I-64::US9867833, Compound I-64(S)

SMILES CCCC1CC(=O)N(C)c2cc(cc3nnc1n23)-c1ccnc(Nc2ccnn2C)n1

InChI Key InChIKey=DBXXOIIQTTULBZ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 365131   

TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM365131(6-methyl-4-(2-((1-methyl- 1H-pyrazol-5- yl)amino)p...)
Affinity DataIC50:  0.149nMAssay Description:Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM365131(6-methyl-4-(2-((1-methyl- 1H-pyrazol-5- yl)amino)p...)
Affinity DataIC50:  0.149nMAssay Description:Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM365131(6-methyl-4-(2-((1-methyl- 1H-pyrazol-5- yl)amino)p...)
Affinity DataIC50:  0.149nMAssay Description:Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent