BDBM365133 9-cyclopropyl-6-methyl- 4-(2-((1-methyl-1H- pyrazol-5- yl)amino)pyrimidin-4-yl)- 8,9-dihydro-1,2,2a1,6- tetraazabenzo[cd]azulen- 7(6H)-one::US10278975, Compound I-65 R::US11376260, Example I-65S::US9867833, Compound I-65(R)

SMILES CN1c2cc(cc3nnc([C@@H](CC1=O)C1CC1)n23)-c1ccnc(Nc2ccnn2C)n1

InChI Key InChIKey=KJDYRXGMEWBQGR-AWEZNQCLSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 365133   

TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM365133(9-cyclopropyl-6-methyl- 4-(2-((1-methyl-1H- pyrazo...)
Affinity DataIC50:  0.660nMAssay Description:Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase 6(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM365133(9-cyclopropyl-6-methyl- 4-(2-((1-methyl-1H- pyrazo...)
Affinity DataIC50:  119nMAssay Description:Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM365133(9-cyclopropyl-6-methyl- 4-(2-((1-methyl-1H- pyrazo...)
Affinity DataIC50:  0.660nMAssay Description:Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent