BDBM365143 9-(4-fluorobenzyl)-6-methyl- 4-(2-((1-methyl-1H-pyrazol- 5-yl)amino)pyridin-4-yl)-8,9- dihydro-1,2,2a1,6- tetraazabenzo[cd]azulen- 7(6H)-one::US10517878, Compound I-70::US10842799, I-70::US9867833, Compound I-70(S)

SMILES CN1c2cc(cc3nnc(C(Cc4ccc(F)cc4)CC1=O)n23)-c1ccnc(Nc2ccnn2C)c1

InChI Key InChIKey=IVTPROIUMJOJGR-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 365143   

TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM365143(9-(4-fluorobenzyl)-6-methyl- 4-(2-((1-methyl-1H-py...)
Affinity DataIC50:  17.2nMAssay Description:Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM365143(9-(4-fluorobenzyl)-6-methyl- 4-(2-((1-methyl-1H-py...)
Affinity DataIC50:  0.316nMAssay Description:Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM365143(9-(4-fluorobenzyl)-6-methyl- 4-(2-((1-methyl-1H-py...)
Affinity DataIC50:  0.316nMAssay Description:Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent