BDBM365170 6-methyl-4-(2-((1-methyl-1H- pyrazol-5-yl)amino)pyridin- 4-yl)-9-(2,2,2-trifluoroethyl)- 8,9-dihydro-1,2,2a1,6- tetraazabenzo[cd]azulen- 7(6H)-one::US10517878, Compound I-86::US10842799, I-86::US9867833, Compound I-86(S)

SMILES CN1c2cc(cc3nnc(C(CC(F)(F)F)CC1=O)n23)-c1ccnc(Nc2ccnn2C)c1

InChI Key InChIKey=FKAMZHMNVQECDN-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 365170   

TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM365170(6-methyl-4-(2-((1-methyl-1H- pyrazol-5-yl)amino)py...)
Affinity DataIC50:  212nMAssay Description:Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM365170(6-methyl-4-(2-((1-methyl-1H- pyrazol-5-yl)amino)py...)
Affinity DataIC50:  9nMAssay Description:Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM365170(6-methyl-4-(2-((1-methyl-1H- pyrazol-5-yl)amino)py...)
Affinity DataIC50:  9nMAssay Description:Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent