BDBM365205 4-(9-isobutyl-8,9-dihydro- 7H-6-oxa-1,2,2a1- triazabenzo[cd]azulen-4-yl)- N-(1-methyl-1H-pyrazol-5- yl)pyrimidin-2-amine::US10517878, Compound I-107::US10842799, I-107::US9867833, Compound I-107(S)

SMILES CC(C)CC1CCOc2cc(cc3nnc1n23)-c1ccnc(Nc2ccnn2C)n1

InChI Key InChIKey=NKTUXELFSTULIE-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 365205   

TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM365205(4-(9-isobutyl-8,9-dihydro- 7H-6-oxa-1,2,2a1- triaz...)
Affinity DataIC50:  0.0230nMAssay Description:Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM365205(4-(9-isobutyl-8,9-dihydro- 7H-6-oxa-1,2,2a1- triaz...)
Affinity DataIC50:  1.85nMAssay Description:Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM365205(4-(9-isobutyl-8,9-dihydro- 7H-6-oxa-1,2,2a1- triaz...)
Affinity DataIC50:  1.85nMAssay Description:Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent