BDBM365314 6-amino-N-[dimethyl(oxido)- lambda4-sulfanylidene]-5-{5-[(3- methyl-2-furoyl)amino]-1- benzothien-2-yl}nicotinamide::US10669265, Example 33::US9868726, Example 33

SMILES Cc1ccoc1C(=O)Nc1ccc2sc(cc2c1)-c1cc(cnc1N)C(=O)N=S(C)(C)=O

InChI Key InChIKey=ATVSJBNYFPDFLL-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 365314   

TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
Allergan

US Patent
LigandPNGBDBM365314(6-amino-N-[dimethyl(oxido)- lambda4-sulfanylidene]...)
Affinity DataIC50:  17nMAssay Description:Biochemical PDGFRβ kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Allergan

US Patent
LigandPNGBDBM365314(6-amino-N-[dimethyl(oxido)- lambda4-sulfanylidene]...)
Affinity DataIC50:  457nMAssay Description:Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
Allergan

US Patent
LigandPNGBDBM365314(6-amino-N-[dimethyl(oxido)- lambda4-sulfanylidene]...)
Affinity DataIC50:  457nMAssay Description:Biochemical PDGFRβ kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Allergan

US Patent
LigandPNGBDBM365314(6-amino-N-[dimethyl(oxido)- lambda4-sulfanylidene]...)
Affinity DataIC50:  6nMAssay Description:Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Allergan

US Patent
LigandPNGBDBM365314(6-amino-N-[dimethyl(oxido)- lambda4-sulfanylidene]...)
Affinity DataIC50:  17nMAssay Description:Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent