BDBM365489 US10533001, Example 205::US11414410, Example 205::US9868729, Example 205

SMILES CNC(=O)[C@@H]1CCCN(C1)c1ccc(Nc2ncc(C(N)=O)c(NC3CC3)n2)cc1

InChI Key InChIKey=CQNHZTVKOGLVDJ-CYBMUJFWSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 365489   

TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Portola Pharmaceuticals

US Patent
LigandPNGBDBM365489(US10533001, Example 205 | US11414410, Example 205 ...)
Affinity DataIC50:  55nMAssay Description:SYK tyrosine phosphorylation activity is measured using the LANCE™ Technology developed by Perkin Elmer Life and Analytical Sciences (Boston, Mass.)....More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Portola Pharmaceuticals

US Patent
LigandPNGBDBM365489(US10533001, Example 205 | US11414410, Example 205 ...)
Affinity DataIC50:  55nMAssay Description:The kinase reaction is performed in a black U-bottom 96-well microtitre plate. The final reaction volume is 50 μL and contains a final concentra...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Portola Pharmaceuticals

US Patent
LigandPNGBDBM365489(US10533001, Example 205 | US11414410, Example 205 ...)
Affinity DataIC50:  55nMAssay Description:Syk and JAK: The activity of a specified compound as an inhibitor of a JAK kinase may be assessed in vitro or in vivo. In some embodiments, the activ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent