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BDBM367246 US10226464, Compound 15

SMILES: COc1ccc2oc3nc(=S)[nH]c(=O)c3cc2c1

InChI Key: InChIKey=XACLKGAPEHFGIP-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 367246   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
nf-kb gfp


(Homo sapiens (Human))
BDBM367246
PNG
(US10226464, Compound 15)
Show SMILES COc1ccc2oc3nc(=S)[nH]c(=O)c3cc2c1
Show InChI InChI=1S/C12H8N2O3S/c1-16-7-2-3-9-6(4-7)5-8-10(15)13-12(18)14-11(8)17-9/h2-5H,1H3,(H,13,15,18)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<3.00E+4n/an/an/an/an/an/a



ImmuneTarget, Inc.

US Patent


Assay Description
NFκB/Jurkat/GFP transcriptional reporter cell line was obtained from SBI System Biosciences. NF-κB/Jurkat/GFP Reporter cells (5105 cells)...


US Patent US10226464 (2019)

More data for this
Ligand-Target Pair
emsa


(Homo sapiens (Human))
BDBM367246
PNG
(US10226464, Compound 15)
Show SMILES COc1ccc2oc3nc(=S)[nH]c(=O)c3cc2c1
Show InChI InChI=1S/C12H8N2O3S/c1-16-7-2-3-9-6(4-7)5-8-10(15)13-12(18)14-11(8)17-9/h2-5H,1H3,(H,13,15,18)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<500n/an/an/an/an/an/a



ImmuneTarget, Inc.

US Patent


Assay Description
DNA binding reaction (20 μL) was carried out in 1DNA Binding Buffer (10 mM Tris, 40 mM NaCl, 1 mM EDTA, 4% glycerol) with 10 nM c-Rel protein a...


US Patent US10226464 (2019)

More data for this
Ligand-Target Pair