BDBM368386 US10227342, Example 21

SMILES COc1ccc(NC(=O)C=C)cc1Nc1ncc(C#N)c(n1)-c1cn(C)c2cc(OCC3CCCN3C)ccc12

InChI Key InChIKey=WTGOEKBHPRCTCB-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 368386   

TargetEpidermal growth factor receptor(Homo sapiens (Human))
Ariad Pharmaceuticals

US Patent
LigandPNGBDBM368386(US10227342, Example 21)
Affinity DataIC50:  750nMAssay Description:A compound's ability in selectively inhibiting EGFR exon 20 insertion mutations can be assessed using Ba/F3 cells, a murine pro-B cell line, whic...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Ariad Pharmaceuticals

US Patent
LigandPNGBDBM368386(US10227342, Example 21)
Affinity DataIC50:  750nMAssay Description:A compound's ability in selectively inhibiting Her2 exon 20 YVMA insertion mutations can be assessed using Ba/F3 cells, a murine pro-B cell line,...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor [T790M](Homo sapiens (Human))
Ariad Pharmaceuticals

US Patent
LigandPNGBDBM368386(US10227342, Example 21)
Affinity DataIC50: <100nMAssay Description:A compound's ability in selectively inhibiting EGFR exon 19 deletion and T790M concurrent mutations can be assessed using Ba/F3 cells, a murine p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Ariad Pharmaceuticals

US Patent
LigandPNGBDBM368386(US10227342, Example 21)
Affinity DataIC50: <100nMAssay Description:A compound's ability in selectively inhibiting EGFR exon 20 insertion mutations can be assessed using Ba/F3 cells, a murine pro-B cell line, whic...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent