BDBM369299 4-[6-(1,3-dimethylpyrazol-4-yl)thieno[3,2- d]pyrimidin-4-yl]-N-[(4- fluorophenyl)methyl]-3,6-dihydro-2H- pyridine-1-carboxamide::US10227357, Compound P-0613

SMILES Cc1nn(C)cc1-c1cc2ncnc(C3=CCN(CC3)C(=O)NCc3ccc(F)cc3)c2s1

InChI Key InChIKey=IEEJCOXTDPKKQB-UHFFFAOYSA-N

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 369299   

TargetMast/stem cell growth factor receptor Kit [D816V](Homo sapiens (Human))
Plexxikon

US Patent
LigandPNGBDBM369299(4-[6-(1,3-dimethylpyrazol-4-yl)thieno[3,2- d]pyrim...)
Affinity DataKi:  500nMAssay Description:The c-Kit mutant D816V inhibitors were assessed using an engineered BaF3-FL KIT D816V or BaF3-FL KIT V560G/D816V cell line. The BaF3-FL KIT D816V cel...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Plexxikon

US Patent
LigandPNGBDBM369299(4-[6-(1,3-dimethylpyrazol-4-yl)thieno[3,2- d]pyrim...)
Affinity DataKi:  5.50E+3nMAssay Description:The c-Kit mutant D816V inhibitors were assessed using an engineered BaF3-FL KIT D816V or BaF3-FL KIT V560G/D816V cell line. The BaF3-FL KIT D816V cel...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent