BDBM369781 US10233160, Compound 72::US9981925, Compound 72

SMILES CNC[C@@H](Nc1ncnc2c(ccnc12)C(N)=O)c1ccc(Cl)c(c1)C(F)(F)F

InChI Key InChIKey=ZGRBCHKVLKCMMT-CYBMUJFWSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 369781   

TargetRibosomal protein S6 kinase beta-1(Homo sapiens (Human))
Merck Patent

US Patent
LigandPNGBDBM369781(US10233160, Compound 72 | US9981925, Compound 72)
Affinity DataIC50: <25nMAssay Description:p70S6K inhibitor compounds were diluted and plated in 96 well plates. A reaction mixture including the following components were then added to the co...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Merck Patent

US Patent
LigandPNGBDBM369781(US10233160, Compound 72 | US9981925, Compound 72)
Affinity DataIC50:  62.5nMAssay Description:In order to measure AKT inhibition in the Caliper Life Sciences LC3000, a TTP Mosquito liquid handling instrument was used to place 125 nl of the app...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRibosomal protein S6 kinase beta-1(Homo sapiens (Human))
Merck Patent

US Patent
LigandPNGBDBM369781(US10233160, Compound 72 | US9981925, Compound 72)
Affinity DataIC50: <25nMAssay Description:p70S6K inhibitor compounds were diluted and plated in 96 well plates. A reaction mixture including the following components were then added to the co...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Merck Patent

US Patent
LigandPNGBDBM369781(US10233160, Compound 72 | US9981925, Compound 72)
Affinity DataIC50: <25nMAssay Description:In order to measure AKT inhibition in the Caliper Life Sciences LC3000, a TTP Mosquito liquid handling instrument was used to place 125 nl of the app...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent