BDBM372965 3-(4,4′-bipyrimidin-6-yl)-5-chlorobenzonitrile::US10246432, Example 6::US10584111, Ex No. 6::US11584732, Example 6

SMILES Clc1cc(cc(c1)-c1cc(ncn1)-c1ccncn1)C#N

InChI Key InChIKey=VLYXEROOFQBMML-UHFFFAOYSA-N

Data  3 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 372965   

TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Heptares Therapeutics

US Patent
LigandPNGBDBM372965(3-(4,4′-bipyrimidin-6-yl)-5-chlorobenzonitri...)
Affinity DataKi:  5.37nMAssay Description:After thawing, membrane homogenates were re-suspended in the binding buffer (50 mM HEPES pH 7.5, 150 mM NaCl) to a final assay concentration of 2.5 &...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Heptares Therapeutics

US Patent
LigandPNGBDBM372965(3-(4,4′-bipyrimidin-6-yl)-5-chlorobenzonitri...)
Affinity DataKi:  5.37nMAssay Description:After thawing, membrane homogenates were re-suspended in the binding buffer (50 mM HEPES pH 7.5, 150 mM NaCl) to a final assay concentration of 2.5 &...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Heptares Therapeutics

US Patent
LigandPNGBDBM372965(3-(4,4′-bipyrimidin-6-yl)-5-chlorobenzonitri...)
Affinity DataKi:  5.37nMAssay Description:Membrane PreparationcDNA encoding the human mGlu5 receptor was transfected into HEK293 cells using the transfection reagent Genejuice (Novagen). Fort...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent