BDBM372967 US10576087, Compound 2.2a::US9895376, Compound 2.2a

SMILES FC(F)(F)c1ccc2nc([nH]c2c1)[C@H]1[C@@H]2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3[C@H]12

InChI Key

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 372967   

TargetSerine/threonine-protein kinase B-raf [V600E](Homo sapiens (Human))
Beigene

US Patent
LigandPNGBDBM372967(US10576087, Compound 2.2a | US9895376, Compound 2....)
Affinity DataIC50:  6.70nMAssay Description:Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetRAF proto-oncogene serine/threonine-protein kinase [Y340D,Y341D](Homo sapiens (Human))
Beigene

US Patent
LigandPNGBDBM372967(US10576087, Compound 2.2a | US9895376, Compound 2....)
Affinity DataIC50:  1.20nMAssay Description:Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine/threonine-protein kinase A-Raf(Homo sapiens (Human))
Albert Einstein College Of Medicine

Curated by ChEMBL
LigandPNGBDBM372967(US10576087, Compound 2.2a | US9895376, Compound 2....)
Affinity DataIC50:  5.60nMAssay Description:Inhibition of ARAF (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Albert Einstein College Of Medicine

Curated by ChEMBL
LigandPNGBDBM372967(US10576087, Compound 2.2a | US9895376, Compound 2....)
Affinity DataIC50:  64nMAssay Description:Inhibition of BRAF V600E mutant in human A375 cells assessed as reduction in ERK phosphorylation after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM372967(US10576087, Compound 2.2a | US9895376, Compound 2....)
Affinity DataIC50:  1.20nMAssay Description:Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Albert Einstein College Of Medicine

Curated by ChEMBL
LigandPNGBDBM372967(US10576087, Compound 2.2a | US9895376, Compound 2....)
Affinity DataIC50:  7nMAssay Description:Inhibition of CRAF (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Albert Einstein College Of Medicine

Curated by ChEMBL
LigandPNGBDBM372967(US10576087, Compound 2.2a | US9895376, Compound 2....)
Affinity DataIC50:  32nMAssay Description:Inhibition of wild type BRAF (unknown origin) using MEK1 as substrate preincubated for 60 to 120 mins followed by substrate addition measured after 2...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf [V600E](Homo sapiens (Human))
Beigene

US Patent
LigandPNGBDBM372967(US10576087, Compound 2.2a | US9895376, Compound 2....)
Affinity DataIC50:  6.70nMAssay Description:Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Albert Einstein College Of Medicine

Curated by ChEMBL
LigandPNGBDBM372967(US10576087, Compound 2.2a | US9895376, Compound 2....)
Affinity DataIC50:  23nMAssay Description:Inhibition of BRAF V600E mutant (unknown origin) using MEK1 as substrate preincubated for 60 to 120 mins followed by substrate addition measured afte...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed