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BDBM373277 US9896452, Example 141::rac-N-(((1s,4s)-2-(2-methyl-5-phenylthiazole-4-carbonyl)-2-azabicyclo[2.2.2]octan-3-yl)methyl)quinoline-8-carboxamide

SMILES: Cc1nc(C(=O)N2C3CCC(CC3)C2CNC(=O)c2cccc3cccnc23)c(s1)-c1ccccc1

InChI Key: InChIKey=KCFDAPJXDCPYPD-UHFFFAOYNA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 373277   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Orexin receptor type 1


(Homo sapiens (Human))
BDBM373277
PNG
(US9896452, Example 141 | rac-N-(((1s,4s)-2-(2-meth...)
Show SMILES Cc1nc(C(=O)N2C3CCC(CC3)C2CNC(=O)c2cccc3cccnc23)c(s1)-c1ccccc1
Show InChI InChI=1/C29H28N4O2S/c1-18-32-26(27(36-18)21-7-3-2-4-8-21)29(35)33-22-14-12-19(13-15-22)24(33)17-31-28(34)23-11-5-9-20-10-6-16-30-25(20)23/h2-11,16,19,22,24H,12-15,17H2,1H3,(H,31,34)
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PC cid
PC sid
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US Patent
n/an/a 2n/an/an/an/an/an/a



EOLAS THERAPEUTICS, INC.

US Patent


Assay Description
Measurement of [Ca2+]i using a FLIPR: CHO-OX1 or CHO-OX2 cells are seeded into black-walled clear-base 384-well plates (Costar) at a density of 20,00...


US Patent US9896452 (2018)

More data for this
Ligand-Target Pair