BDBM373568 1-(6-Cyclohexyl-4-(diethylamino)quinazolin-2-yl)-1H-pyrazole-4-carboxylicacid;::US10246442, Example 27::US10975062, Example 27

SMILES CCN(CC)c1nc(nc2ccc(cc12)C1CCCCC1)-n1cc(cn1)C(O)=O

InChI Key InChIKey=NQNCIRVUWQYYHQ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 373568   

TargetEgl nine homolog 1 [181-417](Homo sapiens (Human))
TBA

US Patent
LigandPNGBDBM373568(1-(6-Cyclohexyl-4-(diethylamino)quinazolin-2-yl)-1...)
Affinity DataIC50:  50.1nMAssay Description:The PHD enzymatic assay was performed in 0.5 ml of reaction mixture containing the following: purified PHD2181-417 polypeptide (3 μg), synthetic...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEgl nine homolog 1 [182-426](Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM373568(1-(6-Cyclohexyl-4-(diethylamino)quinazolin-2-yl)-1...)
Affinity DataIC50:  50.1nMAssay Description:The PHD enzymatic assay was performed in 0.5 ml of reaction mixture containing the following: purified PHD2181-417 polypeptide (3 μg), synthetic...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent