BDBM373711 US10246444, Example 40
SMILES CCOc1cc2ncc(C#N)c(Nc3ccc(OCc4cccc(F)c4)c(Cl)c3)c2cc1NC(=O)CC1CCSS1
InChI Key InChIKey=QCVAULIYZATFDX-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 34 hits for monomerid = 373711
TargetEpidermal growth factor receptor [T790M,L858R](Homo sapiens (Human))
Sabila Biosciences
US Patent
Sabila Biosciences
US Patent
Affinity DataKd: >1.00E+4nMAssay Description:KINOMEscan is based on a competition binding assay that quantitatively measures the ability of a compound to compete with an immobilized, active-site...More data for this Ligand-Target Pair
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of CYP2C8 (unknown origin)More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor [1-751,753-758,760-1210](Homo sapiens (Human))
Sabila Biosciences
US Patent
Sabila Biosciences
US Patent
Affinity DataKd: 50nMAssay Description:KINOMEscan is based on a competition binding assay that quantitatively measures the ability of a compound to compete with an immobilized, active-site...More data for this Ligand-Target Pair
Affinity DataKd: 50nMAssay Description:KINOMEscan is based on a competition binding assay that quantitatively measures the ability of a compound to compete with an immobilized, active-site...More data for this Ligand-Target Pair
Affinity DataKd: 50nMAssay Description:KINOMEscan is based on a competition binding assay that quantitatively measures the ability of a compound to compete with an immobilized, active-site...More data for this Ligand-Target Pair
Affinity DataKd: 50nMAssay Description:KINOMEscan is based on a competition binding assay that quantitatively measures the ability of a compound to compete with an immobilized, active-site...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor [1-746,748-748,750-1210,A750P](Homo sapiens (Human))
Sabila Biosciences
US Patent
Sabila Biosciences
US Patent
Affinity DataKd: 50nMAssay Description:KINOMEscan is based on a competition binding assay that quantitatively measures the ability of a compound to compete with an immobilized, active-site...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor [1-746,748-751,753-1210,P753S](Homo sapiens (Human))
Sabila Biosciences
US Patent
Sabila Biosciences
US Patent
Affinity DataKd: 50nMAssay Description:KINOMEscan is based on a competition binding assay that quantitatively measures the ability of a compound to compete with an immobilized, active-site...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor [1-746,748-750,752-1210](Homo sapiens (Human))
Sabila Biosciences
US Patent
Sabila Biosciences
US Patent
Affinity DataKd: 50nMAssay Description:KINOMEscan is based on a competition binding assay that quantitatively measures the ability of a compound to compete with an immobilized, active-site...More data for this Ligand-Target Pair
Affinity DataIC50: 50nMAssay Description:KINOMEscan is based on a competition binding assay that quantitatively measures the ability of a compound to compete with an immobilized, active-site...More data for this Ligand-Target Pair
Affinity DataIC50: 550nMAssay Description:KINOMEscan is based on a competition binding assay that quantitatively measures the ability of a compound to compete with an immobilized, active-site...More data for this Ligand-Target Pair
Affinity DataIC50: 550nMAssay Description:KINOMEscan is based on a competition binding assay that quantitatively measures the ability of a compound to compete with an immobilized, active-site...More data for this Ligand-Target Pair
Affinity DataIC50: 11nMAssay Description:Inhibition of probe binding to EGFR L858R mutant (unknown origin) using rabbit reticulate lysate system after 1 hr by luminescence assayMore data for this Ligand-Target Pair
Affinity DataKd: 120nMAssay Description:Binding affinity to human partial length wild type EGFR (R669 to V1011 residues) expressed in bacterial expression system by kinomescan assayMore data for this Ligand-Target Pair
Affinity DataKd: 9.60nMAssay Description:Binding affinity to human partial length EGFR L858R mutant (R669 to V1011 residues) expressed in bacterial expression system by kinomescan assayMore data for this Ligand-Target Pair
Affinity DataIC50: 160nMAssay Description:Inhibition of probe binding to HER2 (unknown origin) using rabbit reticulate lysate system after 1 hr by luminescence assayMore data for this Ligand-Target Pair
Affinity DataKd: 13nMAssay Description:Binding affinity to human partial length EGFR L747-T751del/Sins mutant expressed in bacterial expression system by KinomeScan assayMore data for this Ligand-Target Pair
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of CYP1A2 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of CYP2B6 (unknown origin)More data for this Ligand-Target Pair
Affinity DataKd: 14nMAssay Description:Binding affinity to human partial length EGFR G719S mutant (R669 to V1011 residues) expressed in bacterial expression system by KinomeScan assayMore data for this Ligand-Target Pair
Affinity DataKd: 1.00E+4nMAssay Description:Inhibition of human partial length EGFR L858R/T790M mutant (R669 to V1011 residues) expressed in mammalian expression system by competition binding a...More data for this Ligand-Target Pair
Affinity DataKd: 7.90nMAssay Description:Binding affinity to human partial length EGFR L747-E749del/A750P mutant expressed in bacterial expression system by KinomeScan assayMore data for this Ligand-Target Pair
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of CYP2C19 (unknown origin)More data for this Ligand-Target Pair
Affinity DataKd: 10nMAssay Description:Binding affinity to human partial length EGFR S752-I759 deletion mutant expressed in bacterial expression system by KinomeScan assayMore data for this Ligand-Target Pair
Affinity DataKd: 48nMAssay Description:Binding affinity to human partial length EGFR E746-A750 deletion mutant expressed in bacterial expression system by KinomeScan assayMore data for this Ligand-Target Pair
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of CYP2C9 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 120nMAssay Description:Inhibition of probe binding to wild type EGFR (unknown origin) using rabbit reticulate lysate system after 1 hr by luminescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of CYP2D6 (unknown origin)More data for this Ligand-Target Pair
Affinity DataKd: 5.70nMAssay Description:Binding affinity to human partial length EGFR G719C mutant (R669 to V1011 residues) expressed in bacterial expression system by KinomeScan assayMore data for this Ligand-Target Pair
Affinity DataKd: 4.80nMAssay Description:Binding affinity to human partial length EGFR L861Q mutant (R669 to V1011 residues) expressed in bacterial expression system by KinomeScan assayMore data for this Ligand-Target Pair
Affinity DataKd: 12nMAssay Description:Binding affinity to human partial length EGFR L747-S752del/P753S mutant expressed in bacterial expression system by KinomeScan assayMore data for this Ligand-Target Pair
Affinity DataKd: 9.60nMAssay Description:Binding affinity to human partial length EGFR L858R mutant (R669 to V1011 residues) expressed in bacterial expression system under full equilibrating...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor [1-745,747-749,751-1210](Homo sapiens (Human))
Sabila Biosciences
US Patent
Sabila Biosciences
US Patent
Affinity DataKd: 50nMAssay Description:KINOMEscan is based on a competition binding assay that quantitatively measures the ability of a compound to compete with an immobilized, active-site...More data for this Ligand-Target Pair