BDBM373713 US10246444, Example 29

SMILES CCOc1cc2ncc(C#N)c(Nc3ccc(F)c(Cl)c3)c2cc1NC(=O)C(CSC(C)=O)CSC(C)=O

InChI Key InChIKey=ISBDGKGTFDHHAX-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 373713   

TargetEpidermal growth factor receptor(Homo sapiens (Human))
Sabila Biosciences

Curated by ChEMBL
LigandPNGBDBM373713(US10246444, Example 29)
Affinity DataIC50:  494nMAssay Description:Inhibition of probe binding to EGFR L858R mutant (unknown origin) using rabbit reticulate lysate system after 1 hr by luminescence assayMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor [L858R](Homo sapiens (Human))
Sabila Biosciences

US Patent
LigandPNGBDBM373713(US10246444, Example 29)
Affinity DataIC50:  550nMAssay Description:KINOMEscan is based on a competition binding assay that quantitatively measures the ability of a compound to compete with an immobilized, active-site...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent