BDBM374688 1-((R)-1-(2,4-Dichlorophenyl)ethyl)-6-((3R,4S)-4-((S)-2-(hydroxymethyl)pyrrolidin-1-yl)-3-methylcyclohex-1-en-1-yl)-1H-pyrazolo[3,4-b]pyrazine-3-carbonitrile hydrochloride::US10246462, Example 69

SMILES C[C@H](c1ccc(Cl)cc1Cl)n1nc(C#N)c2ncc(nc12)C1=C[C@@H](C)[C@H](CC1)N1CCC[C@H]1CO

InChI Key InChIKey=OCVKUUWYANVQFV-NLFPWZOASA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 374688   

TargetC-C chemokine receptor type 4(Homo sapiens (Human))
Flx Bio

US Patent
LigandPNGBDBM374688(1-((R)-1-(2,4-Dichlorophenyl)ethyl)-6-((3R,4S)-4-(...)
Affinity DataIC50:  300nMAssay Description:To measure binding of 125I-TARC or 125I-MDC to cells expressing CCR4 (e.g., CEM cells (e.g., ATCC HB-12624)), the 125I-TARC or 125I-MDC is diluted to...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent