BDBM374706 1-((R)-1-(2,4-Dichlorophenyl)ethyl)-6-((4S,5R)-4-((2S)-2-(1-hydroxy-2-(methylsulfonyl)ethyl)pyrrolidin-1-yl)-5-methylcyclohex-1-en-1-yl)-1H-pyrazolo[3,4-b]pyrazine-3-carbonitrile hydrochloride::US10246462, Example 87

SMILES C[C@H](c1ccc(Cl)cc1Cl)n1nc(C#N)c2ncc(nc12)C1=CCC([C@H](C)C1)N1CCC[C@H]1C(O)CS(C)(=O)=O

InChI Key InChIKey=HILATWQTNMYNOM-PWVPDILKSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 374706   

TargetC-C chemokine receptor type 4(Homo sapiens (Human))
Flx Bio

US Patent
LigandPNGBDBM374706(1-((R)-1-(2,4-Dichlorophenyl)ethyl)-6-((4S,5R)-4-(...)
Affinity DataIC50: <100nMAssay Description:To measure binding of 125I-TARC or 125I-MDC to cells expressing CCR4 (e.g., CEM cells (e.g., ATCC HB-12624)), the 125I-TARC or 125I-MDC is diluted to...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent