BDBM374715 11-fluoro-3,14-dimethyl-6,7,13,14-tetrahydro-1,15- ethenopyrazolo[4,3- f][1,4,8,10]benzoxatriazacyclotridecin-4(5H)-one::US10246466, Example 40::US10618912, Example 40

SMILES CN1Cc2cc(F)ccc2OCCNC(=O)c2c(C)nn3ccc1nc23

InChI Key InChIKey=QLAIBBCRJCMGRY-UHFFFAOYSA-N

Data  4 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 374715   

TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Tp Therapeutics

US Patent
LigandPNGBDBM374715(11-fluoro-3,14-dimethyl-6,7,13,14-tetrahydro-1,15-...)
Affinity DataKd:  600nMAssay Description:Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., “A small molecule-kinase interactio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProto-oncogene tyrosine-protein kinase ROS(Homo sapiens (Human))
Turning Point Therapeutics

US Patent
LigandPNGBDBM374715(11-fluoro-3,14-dimethyl-6,7,13,14-tetrahydro-1,15-...)
Affinity DataKd:  410nMAssay Description:Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., “A small molecule-kinase interactio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Tp Therapeutics

US Patent
LigandPNGBDBM374715(11-fluoro-3,14-dimethyl-6,7,13,14-tetrahydro-1,15-...)
Affinity DataKd:  600nMAssay Description:Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., “A small molecule-kinase interactio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProto-oncogene tyrosine-protein kinase ROS(Homo sapiens (Human))
Turning Point Therapeutics

US Patent
LigandPNGBDBM374715(11-fluoro-3,14-dimethyl-6,7,13,14-tetrahydro-1,15-...)
Affinity DataKd:  410nMAssay Description:Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., “A small molecule-kinase interactio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent