BDBM374725 12-fluoro-15-methyl-5,6,7,8,14,15-hexahydro-4H- 1,16-ethenopyrazolo[4,3- g][1,5,9,11]benzoxatriazacyclotetradecin-4-one::US10246466, Example 75::US10618912, Example 75

SMILES CN1Cc2cc(F)ccc2OCCCNC(=O)c2cnn3ccc1nc23

InChI Key InChIKey=KWZZATFXFXCGHQ-UHFFFAOYSA-N

Data  4 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 374725   

TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Tp Therapeutics

US Patent
LigandPNGBDBM374725(12-fluoro-15-methyl-5,6,7,8,14,15-hexahydro-4H- 1,...)
Affinity DataKd:  0.0150nMAssay Description:Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., “A small molecule-kinase interactio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Turning Point Therapeutics

US Patent
LigandPNGBDBM374725(12-fluoro-15-methyl-5,6,7,8,14,15-hexahydro-4H- 1,...)
Affinity DataKd:  6.5nMAssay Description:Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., “A small molecule-kinase interactio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Tp Therapeutics

US Patent
LigandPNGBDBM374725(12-fluoro-15-methyl-5,6,7,8,14,15-hexahydro-4H- 1,...)
Affinity DataKd:  0.0150nMAssay Description:Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., “A small molecule-kinase interactio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Turning Point Therapeutics

US Patent
LigandPNGBDBM374725(12-fluoro-15-methyl-5,6,7,8,14,15-hexahydro-4H- 1,...)
Affinity DataKd:  6.5nMAssay Description:Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., “A small molecule-kinase interactio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent