BDBM375158 6-chloro-3-[1-({4-[(4S)-2-::US10253015, Compound I-18

SMILES CC(C)[C@H]1COC(=O)N1c1ccnc(NC(C)c2cc3cc(Cl)ccc3[nH]c2=O)c1

InChI Key

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 375158   

TargetIsocitrate dehydrogenase [NADP] cytoplasmic [R132C](Homo sapiens (Human))
Forma Tm2

US Patent
LigandPNGBDBM375158(6-chloro-3-[1-({4-[(4S)-2- | US10253015, Compound ...)
Affinity DataIC50:  550nMAssay Description:Assays were performed in a 384-well black plate. An aliquot of 250 nL of compound was incubated with 10 μL of 30 nM IDH1-R132H or 10 nM IDH1-R13...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetIsocitrate dehydrogenase [NADP] cytoplasmic [R132H](Homo sapiens (Human))
Forma Tm2

US Patent
LigandPNGBDBM375158(6-chloro-3-[1-({4-[(4S)-2- | US10253015, Compound ...)
Affinity DataIC50:  55nMAssay Description:Assays were performed in a 384-well black plate. An aliquot of 250 nL of compound was incubated with 10 μL of 30 nM IDH1-R132H or 10 nM IDH1-R13...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent