BDBM375231 3-chloro-6-(5-fluoropyridin-3-yl)-5-(3-fluoropyridin-4-yl)pyridin-2-amine::US10253017, Example 27

SMILES Nc1cc(Cl)c(-c2ccnc(F)c2)c(n1)-c1cncc(F)c1

InChI Key InChIKey=YERBUXPLLAAXPI-UHFFFAOYSA-N

Data  2 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 375231   

TargetAdenosine receptor A2b(Homo sapiens (Human))
Palobiofarma

US Patent
LigandPNGBDBM375231(3-chloro-6-(5-fluoropyridin-3-yl)-5-(3-fluoropyrid...)
Affinity DataKi:  150nMAssay Description:The binding assay for adenosine A2B receptor subtype was carried out on human recombinant source (HEK-293 cells) and [3H]DPCPX as radioligand, accord...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAdenosine receptor A2a(Homo sapiens (Human))
Palobiofarma

US Patent
LigandPNGBDBM375231(3-chloro-6-(5-fluoropyridin-3-yl)-5-(3-fluoropyrid...)
Affinity DataKi: >5.00E+3nMAssay Description:The binding assay for adenosine A2B receptor subtype was carried out on human recombinant source (HEK-293 cells) and [3H]DPCPX as radioligand, accord...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRibosyldihydronicotinamide dehydrogenase [quinone](Homo sapiens (Human))
Palobiofarma

US Patent
LigandPNGBDBM375231(3-chloro-6-(5-fluoropyridin-3-yl)-5-(3-fluoropyrid...)
Affinity DataIC50:  250nMAssay Description:The experiment of binding to MT3 sites was carried out on hamster brain membranes using [125I]2-iodomelatonin as radioligand in accordance with the p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent