BDBM375331 US10358436, Example A51::US9907800, Example A177::US9907800, Example A51
SMILES COc1ccc2NC(=O)[C@@]3(C[C@H]3c3ccc4c(\C=C\c5ccc(CCN6CCOCC6)cc5)n[nH]c4c3)c2c1
InChI Key
Data 14 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 14 hits for monomerid = 375331
Affinity DataIC50: <100nMAssay Description:PLK4 activity was measured using an indirect ELISA detection system. Dephosphorylated GST-PLK4 (4 nM) was incubated in the presence of 15 μM ATP...More data for this Ligand-Target Pair
Affinity DataIC50: <100nMAssay Description:Aurora A inhibition was determined using the Z-Lyte assay kit from Invitrogen. The assay was performed using the recommended manufacturer's instr...More data for this Ligand-Target Pair
Affinity DataIC50: <100nMAssay Description:Aurora B inhibition was determined using the Z-Lyte assay kit from Invitrogen. The assay was performed using the recommended manufacturer's instr...More data for this Ligand-Target Pair
Affinity DataIC50: <100nMAssay Description:PLK4 activity was measured using an indirect ELISA detection system. Dephosphorylated GST-PLK4 (4 nM) was incubated in the presence of 15 μM ATP...More data for this Ligand-Target Pair
Affinity DataIC50: <100nMAssay Description:Aurora B inhibition was determined using the Z-Lyte assay kit from Invitrogen. The assay was performed using the recommended manufacturer's instr...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase PLK4 [1-391](Homo sapiens (Human))
University Health Network
US Patent
University Health Network
US Patent
Affinity DataIC50: <100nMAssay Description:Active PLK4 was purified from an E. coli expression system as an amino terminal GST fusion of residues 1-391 of human PLK4. The protein was purified ...More data for this Ligand-Target Pair
Affinity DataIC50: <100nMAssay Description:Aurora B inhibition was determined using the Z-Lyte assay kit from Invitrogen. The assay was performed using the recommended manufacturer's instr...More data for this Ligand-Target Pair
Affinity DataIC50: <100nMAssay Description:Aurora B inhibition was determined using the Z-Lyte assay kit from Invitrogen. The assay was performed using the recommended manufacturer's instr...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase PLK4 [1-391](Homo sapiens (Human))
University Health Network
US Patent
University Health Network
US Patent
Affinity DataIC50: <100nMAssay Description:Active PLK4 was purified from an E. coli expression system as an amino terminal GST fusion of residues 1-391 of human PLK4. The protein was purified ...More data for this Ligand-Target Pair
Affinity DataIC50: <500nMAssay Description:Aurora A inhibition was determined using the Z-Lyte assay kit from Invitrogen. The assay was performed using the recommended manufacturer's instr...More data for this Ligand-Target Pair
Affinity DataIC50: <100nMAssay Description:Aurora B inhibition was determined using the Z-Lyte assay kit from Invitrogen. The assay was performed using the recommended manufacturer's instr...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase PLK4 [1-391](Homo sapiens (Human))
University Health Network
US Patent
University Health Network
US Patent
Affinity DataIC50: <100nMAssay Description:Active PLK4 was purified from an E. coli expression system as an amino terminal GST fusion of residues 1-391 of human PLK4. The protein was purified ...More data for this Ligand-Target Pair
Affinity DataIC50: <100nMAssay Description:Aurora A inhibition was determined using the Z-Lyte assay kit from Invitrogen. The assay was performed using the recommended manufacturer's instr...More data for this Ligand-Target Pair
Affinity DataIC50: <100nMAssay Description:Aurora A inhibition was determined using the Z-Lyte assay kit from Invitrogen. The assay was performed using the recommended manufacturer's instr...More data for this Ligand-Target Pair