BDBM375470 US9907800, Example A179

SMILES COc1ccc2NC(=O)[C@@]3(CC3c3ccc4c(\C=C\c5ccc(cc5)C(=O)N5CCN(C)CC5)n[nH]c4c3)c2c1

InChI Key

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 375470   

TargetSerine/threonine-protein kinase PLK4(Homo sapiens (Human))
University Health Network

US Patent
LigandPNGBDBM375470(US9907800, Example A179)
Affinity DataIC50: <100nMAssay Description:PLK4 activity was measured using an indirect ELISA detection system. Dephosphorylated GST-PLK4 (4 nM) was incubated in the presence of 15 μM ATP...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAurora kinase B(Homo sapiens (Human))
University Health Network

US Patent
LigandPNGBDBM375470(US9907800, Example A179)
Affinity DataIC50: <100nMAssay Description:Aurora B inhibition was determined using the Z-Lyte assay kit from Invitrogen. The assay was performed using the recommended manufacturer's instr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAurora kinase A(Homo sapiens (Human))
University Health Network

US Patent
LigandPNGBDBM375470(US9907800, Example A179)
Affinity DataIC50: <100nMAssay Description:Aurora A inhibition was determined using the Z-Lyte assay kit from Invitrogen. The assay was performed using the recommended manufacturer's instr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent