BDBM375886 US9914731, Ex. No. 105

SMILES Fc1ccc(cc1)-n1cccc(C(=O)Nc2ccc(Oc3cc(cn4nccc34)-c3cncs3)c(F)c2)c1=O

InChI Key InChIKey=BFUSNYLLYCPFER-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 375886   

TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Ignyta

US Patent
LigandPNGBDBM375886(US9914731, Ex. No. 105)
Affinity DataIC50: <10nMAssay Description:The cMET kinase assay was performed in 384-well Fluotrac™ 200 HiBase microplates using the HTRF KinEASE™ assay described above for AXL except that th...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase receptor UFO(Homo sapiens (Human))
Ignyta

US Patent
LigandPNGBDBM375886(US9914731, Ex. No. 105)
Affinity DataIC50:  55nMAssay Description:The ability of compounds to inhibit the kinase activity of recombinant human baculovirus-expressed AXL was measured by homogeneous TRF (HTRF) using C...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent