BDBM376609 6'-(3-Chloro-4-fluorophenyl)-5-methyl-5'',6''-dihydro-4''H-dispiro[imidazole-2,4'-chromene-2',3''-pyran]-4-amine::US9918985, Example 46b Isomer 1

SMILES CC1=N[C@]2(C[C@@]3(CCCOC3)Oc3ccc(cc23)-c2ccc(F)c(Cl)c2)N=C1N

InChI Key InChIKey=AMESWUXBYLEHJV-FGZHOGPDSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 376609   

TargetBeta-secretase 1 [1-460](Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM376609(6'-(3-Chloro-4-fluorophenyl)-5-methyl-5'',6''-dihy...)
Affinity DataIC50:  180nMAssay Description:The enzyme (truncated form) was diluted to 6 μg/mL (stock 1.3 mg/mL) and the substrate (Europium)CEVNLDAEFK(Qsy7) to 200 nM (stock 120 μM) ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent