BDBM376642 4-(Cyclobutyloxy)-1-methyl-5-(6-methyl- 7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c] pyridin-4-yl)-1,3-dihydro-2H- benzimidazol-2-one::US9918990, Example 89

SMILES Cn1c2ccc(c(OC3CCC3)c2[nH]c1=O)-c1cn(C)c(=O)c2[nH]ccc12

InChI Key InChIKey=RXTWMEUCNDJJDS-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 376642   

TargetBromodomain-containing protein 2(Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM376642(4-(Cyclobutyloxy)-1-methyl-5-(6-methyl- 7-oxo-6,7-...)
Affinity DataIC50: <100nMAssay Description:BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM376642(4-(Cyclobutyloxy)-1-methyl-5-(6-methyl- 7-oxo-6,7-...)
Affinity DataIC50: <100nMAssay Description:BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent