BDBM376674 N-{4-[(1R,3S,5S)-3-Amino-5-methylcyclohexyl]pyridin-3-yl}-3-[(3R)-3-cyanopyrrolidin-1-yl]-5-fluoroquinoline-8-carboxamide::US10450296, Example 8::US11053215, Example 8::US9920032, Example 8

SMILES C[C@@H]1C[C@H](N)C[C@@H](C1)c1ccncc1NC(=O)c1ccc(F)c2cc(cnc12)N1CC[C@H](C1)C#N

InChI Key InChIKey=VXLVJOPKTAHBGM-OKYOBFRVSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 376674   

TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM376674(N-{4-[(1R,3S,5S)-3-Amino-5-methylcyclohexyl]pyridi...)
Affinity DataIC50: <10nMAssay Description:Pim-1 and Pim-3 kinase assays—20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase pim-2(Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM376674(N-{4-[(1R,3S,5S)-3-Amino-5-methylcyclohexyl]pyridi...)
Affinity DataIC50: <100nMAssay Description:Pim-2 kinase assay—20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay buffer (50 m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase pim-3(Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM376674(N-{4-[(1R,3S,5S)-3-Amino-5-methylcyclohexyl]pyridi...)
Affinity DataIC50: <10nMAssay Description:Pim-1 and Pim-3 kinase assays—20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM376674(N-{4-[(1R,3S,5S)-3-Amino-5-methylcyclohexyl]pyridi...)
Affinity DataIC50: <10nMAssay Description:Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase pim-3(Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM376674(N-{4-[(1R,3S,5S)-3-Amino-5-methylcyclohexyl]pyridi...)
Affinity DataIC50: <10nMAssay Description:Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase pim-3(Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM376674(N-{4-[(1R,3S,5S)-3-Amino-5-methylcyclohexyl]pyridi...)
Affinity DataIC50: <10nMAssay Description:Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM376674(N-{4-[(1R,3S,5S)-3-Amino-5-methylcyclohexyl]pyridi...)
Affinity DataIC50: <10nMAssay Description:Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase pim-2(Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM376674(N-{4-[(1R,3S,5S)-3-Amino-5-methylcyclohexyl]pyridi...)
Affinity DataIC50: <100nMAssay Description:Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase pim-2(Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM376674(N-{4-[(1R,3S,5S)-3-Amino-5-methylcyclohexyl]pyridi...)
Affinity DataIC50: <100nMAssay Description:Pim-2 kinase assay-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay buffer (50 m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent