BDBM376887 4-(aminomethyl)-1-[2-fluoro-3-(3-fluorophenoxy)phenyl]piperidin-4-ol (E17)::US9920053, Example 17

SMILES NCC1(O)CCN(CC1)c1cccc(Oc2cccc(F)c2)c1F

InChI Key InChIKey=CVRLXTFHTBLFPY-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 376887   

TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Chronos Therapeutics

US Patent
LigandPNGBDBM376887(4-(aminomethyl)-1-[2-fluoro-3-(3-fluorophenoxy)phe...)
Affinity DataIC50:  6.76nMAssay Description:The affinity of the compounds of the invention to the human DAT or NET or SERT transporters is assessed by using the [3H]WIN-35,428 or [3H]nisoxetine...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Chronos Therapeutics

US Patent
LigandPNGBDBM376887(4-(aminomethyl)-1-[2-fluoro-3-(3-fluorophenoxy)phe...)
Affinity DataIC50:  2.09E+3nMAssay Description:The affinity of the compounds of the invention to the human DAT or NET or SERT transporters is assessed by using the [3H]WIN-35,428 or [3H]nisoxetine...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Chronos Therapeutics

US Patent
LigandPNGBDBM376887(4-(aminomethyl)-1-[2-fluoro-3-(3-fluorophenoxy)phe...)
Affinity DataIC50:  324nMAssay Description:The affinity of the compounds of the invention to the human DAT or NET or SERT transporters is assessed by using the [3H]WIN-35,428 or [3H]nisoxetine...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent