BDBM376898 N-({1-[4-(3-fluorophenoxy)-6-(trifluoromethyl)pyrimidin-2-yl]-4-hydroxypiperidin-4-yl}methyl)pyrazine-2-carboxamide (E28)::US9920053, Example 28

SMILES OC1(CNC(=O)c2cnccn2)CCN(CC1)c1nc(Oc2cccc(F)c2)cc(n1)C(F)(F)F

InChI Key InChIKey=GECVFCYHTYLHEA-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 376898   

TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Chronos Therapeutics

US Patent
LigandPNGBDBM376898(N-({1-[4-(3-fluorophenoxy)-6-(trifluoromethyl)pyri...)
Affinity DataIC50:  13.8nMAssay Description:The affinity of the compounds of the invention to the human DAT or NET or SERT transporters is assessed by using the [3H]WIN-35,428 or [3H]nisoxetine...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Chronos Therapeutics

US Patent
LigandPNGBDBM376898(N-({1-[4-(3-fluorophenoxy)-6-(trifluoromethyl)pyri...)
Affinity DataIC50:  3.16E+3nMAssay Description:The affinity of the compounds of the invention to the human DAT or NET or SERT transporters is assessed by using the [3H]WIN-35,428 or [3H]nisoxetine...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Chronos Therapeutics

US Patent
LigandPNGBDBM376898(N-({1-[4-(3-fluorophenoxy)-6-(trifluoromethyl)pyri...)
Affinity DataIC50: <1.00E+5nMAssay Description:The affinity of the compounds of the invention to the human DAT or NET or SERT transporters is assessed by using the [3H]WIN-35,428 or [3H]nisoxetine...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Chronos Therapeutics

US Patent
LigandPNGBDBM376898(N-({1-[4-(3-fluorophenoxy)-6-(trifluoromethyl)pyri...)
Affinity DataIC50:  1.10E+3nMAssay Description:The affinity of the compounds of the invention to the human DAT or NET or SERT transporters is assessed by using the [3H]WIN-35,428 or [3H]nisoxetine...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent