BDBM377636 3-({[3-methoxy-4-(1H-1,2,3,4-tetrazol-1-::US10266495, Compound I-48
SMILES COc1cc(NCc2cc3ccccc3[nH]c2=O)ccc1-n1cnnn1
InChI Key InChIKey=JGXVUDGASVPOGG-UHFFFAOYSA-N
Data 2 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 2 hits for monomerid = 377636
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Homo sapiens (Human))
Forma Therapeutics
Curated by ChEMBL
Forma Therapeutics
Curated by ChEMBL
Affinity DataIC50: 3.32E+3nMAssay Description:Inhibition of human Myc-DDK-tagged IDH1 R132H mutant assessed as reduction in NADPH consumption pre-incubated for 15 mins followed by alpha-ketogluta...More data for this Ligand-Target Pair
TargetIsocitrate dehydrogenase [NADP] cytoplasmic [R132H](Homo sapiens (Human))
Sunshine Lake Pharma
US Patent
Sunshine Lake Pharma
US Patent
Affinity DataIC50: >1.00E+3nMAssay Description:Assays were performed in a 384-well black plate. An aliquot of 250 nL of compound was incubated with 10 μL of 30 nM IDH1-R132H or 10 nM IDH1-R13...More data for this Ligand-Target Pair