BDBM377639 6,7-dimethyl-3-({[4-(1H-1,2,3,4-tetrazol-1-::US10266495, Compound I-51

SMILES Cc1cc2cc(CNc3ccc(cc3)-n3cnnn3)c(=O)[nH]c2cc1C

InChI Key InChIKey=UNQLYSBMVVGBRH-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 377639   

TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Homo sapiens (Human))
Forma Therapeutics

Curated by ChEMBL
LigandPNGBDBM377639(6,7-dimethyl-3-({[4-(1H-1,2,3,4-tetrazol-1- | US10...)
Affinity DataIC50:  3.11E+3nMAssay Description:Inhibition of human Myc-DDK-tagged IDH1 R132H mutant assessed as reduction in NADPH consumption pre-incubated for 15 mins followed by alpha-ketogluta...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIsocitrate dehydrogenase [NADP] cytoplasmic [R132H](Homo sapiens (Human))
Sunshine Lake Pharma

US Patent
LigandPNGBDBM377639(6,7-dimethyl-3-({[4-(1H-1,2,3,4-tetrazol-1- | US10...)
Affinity DataIC50: >1.00E+3nMAssay Description:Assays were performed in a 384-well black plate. An aliquot of 250 nL of compound was incubated with 10 μL of 30 nM IDH1-R132H or 10 nM IDH1-R13...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent