BDBM377668 4-[({6-chloro-2-oxo-7-[2-(pyridin-2-yl)ethoxy]-1,2-::US10266495, Compound I-80

SMILES COc1cc(NCc2cc3cc(Cl)c(OCCc4ccccn4)cc3[nH]c2=O)ccc1C#N

InChI Key InChIKey=ZKPLTVZRYJMSDR-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 377668   

TargetIsocitrate dehydrogenase [NADP] cytoplasmic [R132C](Homo sapiens (Human))
Sunshine Lake Pharma

US Patent
LigandPNGBDBM377668(4-[({6-chloro-2-oxo-7-[2-(pyridin-2-yl)ethoxy]-1,2...)
Affinity DataIC50: >1.00E+3nMAssay Description:Assays were performed in a 384-well black plate. An aliquot of 250 nL of compound was incubated with 10 μL of 30 nM IDH1-R132H or 10 nM IDH1-R13...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetIsocitrate dehydrogenase [NADP] cytoplasmic [R132H](Homo sapiens (Human))
Sunshine Lake Pharma

US Patent
LigandPNGBDBM377668(4-[({6-chloro-2-oxo-7-[2-(pyridin-2-yl)ethoxy]-1,2...)
Affinity DataIC50:  55nMAssay Description:Assays were performed in a 384-well black plate. An aliquot of 250 nL of compound was incubated with 10 μL of 30 nM IDH1-R132H or 10 nM IDH1-R13...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent