BDBM377678 4-[({6-chloro-7-[2-(2-methyl-1H-imidazol-1-::US10266495, Compound I-90

SMILES COc1cc(NCc2cc3cc(Cl)c(OCCn4ccnc4C)cc3[nH]c2=O)ccc1C#N

InChI Key InChIKey=LWWFYUMGJBBWIN-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 377678   

TargetIsocitrate dehydrogenase [NADP] cytoplasmic [R132C](Homo sapiens (Human))
Sunshine Lake Pharma

US Patent
LigandPNGBDBM377678(4-[({6-chloro-7-[2-(2-methyl-1H-imidazol-1- | US10...)
Affinity DataIC50:  550nMAssay Description:Assays were performed in a 384-well black plate. An aliquot of 250 nL of compound was incubated with 10 μL of 30 nM IDH1-R132H or 10 nM IDH1-R13...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetIsocitrate dehydrogenase [NADP] cytoplasmic [R132H](Homo sapiens (Human))
Sunshine Lake Pharma

US Patent
LigandPNGBDBM377678(4-[({6-chloro-7-[2-(2-methyl-1H-imidazol-1- | US10...)
Affinity DataIC50:  55nMAssay Description:Assays were performed in a 384-well black plate. An aliquot of 250 nL of compound was incubated with 10 μL of 30 nM IDH1-R132H or 10 nM IDH1-R13...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent