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BDBM377760 5-amino-1-(1-cyanopiperidin-3-yl)- 3-[4-(3-fluoro-2- methylphenoxy)phenyl]-1H- pyrazole-4-carboxamide::US10266513, Example 54

SMILES: Cc1c(F)cccc1Oc1ccc(cc1)-c1nn(C2CCCN(C2)C#N)c(N)c1C(N)=O

InChI Key: InChIKey=UQLSUNKPTWQFTD-UHFFFAOYNA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 377760   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM377760
PNG
(5-amino-1-(1-cyanopiperidin-3-yl)- 3-[4-(3-fluoro-...)
Show SMILES Cc1c(F)cccc1Oc1ccc(cc1)-c1nn(C2CCCN(C2)C#N)c(N)c1C(N)=O
Show InChI InChI=1/C23H23FN6O2/c1-14-18(24)5-2-6-19(14)32-17-9-7-15(8-10-17)21-20(23(27)31)22(26)30(28-21)16-4-3-11-29(12-16)13-25/h2,5-10,16H,3-4,11-12,26H2,1H3,(H2,27,31)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 1.20n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide peptid...


US Patent US10266513 (2019)

More data for this
Ligand-Target Pair