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BDBM377761 5-amino-1-(1-cyanopiperidin-3-yl)- 3-[4-(2,5-dichlorophenoxy)phenyl]- 1H-pyrazole-4-carboxamide::US10266513, Example 55

SMILES: NC(=O)c1c(N)n(nc1-c1ccc(Oc2cc(Cl)ccc2Cl)cc1)C1CCCN(C1)C#N

InChI Key: InChIKey=HRCLPQPDRKXZCD-UHFFFAOYNA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 377761   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM377761
PNG
(5-amino-1-(1-cyanopiperidin-3-yl)- 3-[4-(2,5-dichl...)
Show SMILES NC(=O)c1c(N)n(nc1-c1ccc(Oc2cc(Cl)ccc2Cl)cc1)C1CCCN(C1)C#N
Show InChI InChI=1/C22H20Cl2N6O2/c23-14-5-8-17(24)18(10-14)32-16-6-3-13(4-7-16)20-19(22(27)31)21(26)30(28-20)15-2-1-9-29(11-15)12-25/h3-8,10,15H,1-2,9,11,26H2,(H2,27,31)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 2.20n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide peptid...


US Patent US10266513 (2019)

More data for this
Ligand-Target Pair