BDBM378903 7-((5,8-dichloro-7-(methoxy(oxetan-3-yl)methyl)-1-oxo-3,4-dihydroisoquinolin-2(1H)-yl)methyl)-4-methylfuro[3,2-c]pyridin-6(5H)-on::US10266542, Example 9

SMILES COC(C1COC1)c1cc(Cl)c2CCN(Cc3c4occc4c(C)[nH]c3=O)C(=O)c2c1Cl

InChI Key

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 378903   

TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Mirati Therapeutics

US Patent
LigandPNGBDBM378903(7-((5,8-dichloro-7-(methoxy(oxetan-3-yl)methyl)-1-...)
Affinity DataIC50:  4nMAssay Description:Ten-point dose-response curves for a subset of compounds shown in Table 1 were determined using a TranscreenerŽ EPIGEN Methyltransferase HTS assay us...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent