BDBM378907 5,8-dichloro-7-(3,5-dimethylisoxazol-4-yl)-2-((7-methyl-5-oxo-5,6-dihydro-1H-pyrrolo[2,3-c]pyridin-4-yl)methyl)-3,4-dihydroisoquinolin-1 (2H)-one::US10266542, Example 13

SMILES Cc1noc(C)c1-c1cc(Cl)c2CCN(Cc3c4cc[nH]c4c(C)[nH]c3=O)C(=O)c2c1Cl

InChI Key InChIKey=KKGAZDPMJJHIND-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 378907   

TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Affiliated Hospital Of Guangdong Medical University

Curated by ChEMBL
LigandPNGBDBM378907(5,8-dichloro-7-(3,5-dimethylisoxazol-4-yl)-2-((7-m...)
Affinity DataIC50:  2nMAssay Description:Inhibition of EZH2 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Affiliated Hospital Of Guangdong Medical University

Curated by ChEMBL
LigandPNGBDBM378907(5,8-dichloro-7-(3,5-dimethylisoxazol-4-yl)-2-((7-m...)
Affinity DataIC50:  2nMAssay Description:Ten-point dose-response curves for a subset of compounds shown in Table 1 were determined using a TranscreenerŽ EPIGEN Methyltransferase HTS assay us...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent