BDBM379678 US9926281, Compound 204
SMILES C[C@H]1CN(CCN1c1cc(Cl)cc(Cl)c1)C(=O)CC[C@]1(NC(=O)NC1=O)C1CC1
InChI Key InChIKey=BTEUURMBUUDUGB-YUNKPMOVSA-N
Data 6 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 6 hits for monomerid = 379678
Affinity DataIC50: 11nMAssay Description:ADAMTS-4:The basis for the assay is the cleavage of the substrate TBIS-1 (5-FAM-TEGEARGSVILLK (5TAMRA)K-NH2) (SEQ ID No 2) by human ADAMTS4For the do...More data for this Ligand-Target Pair
TargetA disintegrin and metalloproteinase with thrombospondin motifs 5(Homo sapiens (Human))
Galapagos
US Patent
Galapagos
US Patent
Affinity DataIC50: 16nMAssay Description:ADAMTS-5:Protocol 2: The basis for the assay is the cleavage of the substrate TBIS-1 (5 FAM-TEGEARGSVILLK (5TAMRA)K-NH2) (SEQ ID No 2) by human ADAMT...More data for this Ligand-Target Pair
Affinity DataIC50: >2.00E+4nMAssay Description:MMP-14:The basis for the assay is the cleavage of the substrate 390 MMP FRET Substrate I (Anaspec Cat # AS-27076) by human MMP14 (Biomol, Cat #SE-259...More data for this Ligand-Target Pair
Affinity DataIC50: >2.00E+4nMAssay Description:MMP2: Protocol 2: The basis for the assay is the cleavage of the substrate 390 MMP FRET substrate I (Anaspec, Catalog n#: AS-27076) by human MMP2 (R&...More data for this Ligand-Target Pair
Affinity DataIC50: >1.20E+4nMAssay Description:MMP-13:The basis for the assay is the cleavage of the substrate 390 MMP FRET Substrate I (Anaspec Cat # AS-27076) by human MMP13 (Chemicon, Cat #CC06...More data for this Ligand-Target Pair
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Galapagos
US Patent
Galapagos
US Patent
Affinity DataIC50: 3.87E+3nMAssay Description:TACE:The basis for the assay is the cleavage of the substrate 5FAM-LAQAVRSSSRK-5TAMRA (SEQ ID No 3) (Anaspec, custom 34891) by human TACE (R&D SYSTEM...More data for this Ligand-Target Pair