BDBM380318 N-[3-methyl-4-(4-oxo- 3,4-dihydrophthalazin- 1-yl)phenyl]-1-(oxan- 4-ylmethyl)-1H- indazole-3- carboxamide::US9926282, Example 313

SMILES Cc1cc(NC(=O)c2nn(CC3CCOCC3)c3ccccc23)ccc1-c1n[nH]c(=O)c2ccccc12

InChI Key InChIKey=FLSVOEHBTHXAPI-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 380318   

TargetRho-associated protein kinase 2(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM380318(N-[3-methyl-4-(4-oxo- 3,4-dihydrophthalazin- 1-yl)...)
Affinity DataIC50: <100nMAssay Description:The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM380318(N-[3-methyl-4-(4-oxo- 3,4-dihydrophthalazin- 1-yl)...)
Affinity DataIC50: <100nMAssay Description:The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent