BDBM380447 5-[3-(Cyanomethyl)-3-(3′-ethyl-1H,1′H-4,4′-bipyrazol-1-yl)azetidin-1-yl]-N-[(1S)-2,2,2-trifluoro-1-methylethyl]pyrazine-2-carboxamide trifluoroacetate::US10435392, Example 11::US9926301, Example 11

SMILES CCc1n[nH]cc1-c1cnn(c1)C1(CC#N)CN(C1)c1cnc(cn1)C(=O)N[C@@H](C)C(F)(F)F

InChI Key

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 380447   

TargetTyrosine-protein kinase JAK1 [837-1142](Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM380447(5-[3-(Cyanomethyl)-3-(3′-ethyl-1H,1′H-...)
Affinity DataIC50:  650nMAssay Description:Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK2 [828-1132](Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM380447(5-[3-(Cyanomethyl)-3-(3′-ethyl-1H,1′H-...)
Affinity DataIC50: >1.00E+3nMAssay Description:Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK1 [837-1142](Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM380447(5-[3-(Cyanomethyl)-3-(3′-ethyl-1H,1′H-...)
Affinity DataIC50:  650nMAssay Description:Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK2 [828-1132](Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM380447(5-[3-(Cyanomethyl)-3-(3′-ethyl-1H,1′H-...)
Affinity DataIC50: >700nMAssay Description:Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent