BDBM380973 6-(4-Hydroxy-4-methyl-3,4-dihydro- 1H-pyrano[4,3-c]pyridin-8-yl)-1- methyl-1H-indazole-3-carbonitrile, Enantiomer I::US9890171, 177::US9890171, 178

SMILES Cn1nc(C#N)c2ccc(cc12)-c1cncc2c1COCC2(C)O

InChI Key InChIKey=IZBRBDMDXUPWCO-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 380973   

TargetCytochrome P450 11B2, mitochondrial(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM380973(6-(4-Hydroxy-4-methyl-3,4-dihydro- 1H-pyrano[4,3-c...)
Affinity DataIC50:  15nMAssay Description:The aldosterone synthase inhibition assay employs cynomolgus adrenal gland mitochondria as the source of aldosterone synthase (CYP11B2). Mitochondria...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCytochrome P450 11B2, mitochondrial(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM380973(6-(4-Hydroxy-4-methyl-3,4-dihydro- 1H-pyrano[4,3-c...)
Affinity DataIC50:  42.8nMAssay Description:The aldosterone synthase inhibition assay employs cynomolgus adrenal gland mitochondria as the source of aldosterone synthase (CYP11B2). Mitochondria...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent