BindingDB logo
myBDB logout

BDBM382120 5-(4-(4-chloro-2-fluorophenoxy)piperidin-1-yl)-6-(cyclopropylamino)pyrazine-2-carbonitrile::US10000468, Example 29::US10273225, Example 29

SMILES: Fc1cc(Cl)ccc1OC1CCN(CC1)c1ncc(nc1NC1CC1)C#N

InChI Key: InChIKey=OGSYEOBSSCBGKI-UHFFFAOYSA-N

Data: 2 EC50

Find this compound or compounds like it in BindingDB:
Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 382120   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
G-protein coupled receptor 6


(Homo sapiens (Human))
BDBM382120
PNG
(5-(4-(4-chloro-2-fluorophenoxy)piperidin-1-yl)-6-(...)
Show SMILES Fc1cc(Cl)ccc1OC1CCN(CC1)c1ncc(nc1NC1CC1)C#N
Show InChI InChI=1S/C19H19ClFN5O/c20-12-1-4-17(16(21)9-12)27-15-5-7-26(8-6-15)19-18(24-13-2-3-13)25-14(10-22)11-23-19/h1,4,9,11,13,15H,2-3,5-8H2,(H,24,25)
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 1.84E+5n/an/an/an/a



Takeda Pharmaceutical Co., Ltd

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...


US Patent US10273225 (2019)


BindingDB Entry DOI: 10.7270/Q24X5B3J
More data for this
Ligand-Target Pair
G-protein coupled receptor 6


(Homo sapiens (Human))
BDBM382120
PNG
(5-(4-(4-chloro-2-fluorophenoxy)piperidin-1-yl)-6-(...)
Show SMILES Fc1cc(Cl)ccc1OC1CCN(CC1)c1ncc(nc1NC1CC1)C#N
Show InChI InChI=1S/C19H19ClFN5O/c20-12-1-4-17(16(21)9-12)27-15-5-7-26(8-6-15)19-18(24-13-2-3-13)25-14(10-22)11-23-19/h1,4,9,11,13,15H,2-3,5-8H2,(H,24,25)
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 1.84E+5n/an/an/an/a



Takeda Pharmaceutical Co., Ltd

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...


US Patent US10000468 (2018)


BindingDB Entry DOI: 10.7270/Q23R0W71
More data for this
Ligand-Target Pair